ENSPRYNG^® and Thyroid Eye Disease (TED) FAQs

ENSPRYNG is a prescription medication approved for TED that has been proven to improve eye bulging and double vision. It is a self-administered injection given under the skin.

After proper training by your healthcare provider, and if they determine it is appropriate, you or your caregiver have the ability to give it in the comfort of your own home.

ENSPRYNG is approved for adults with TED, no matter how long they’ve had the condition or whether the disease is active.

Do not take ENSPRYNG if you:

• Are allergic to ENSPRYNG or any of the ingredients in ENSPRYNG.
• Have an active hepatitis B infection.
• Have active or untreated inactive (latent) tuberculosis.

The specific way ENSPRYNG works is not completely understood, but it is thought to involve the protein interleukin 6 (IL-6). IL-6 is a protein made by immune cells in our bodies and may play a key role in inflammation that occurs in people with TED.

ENSPRYNG is the first and only FDA-approved treatment for TED that is designed to target the action of IL-6.

Genentech Access Solutions will tell you which specialty pharmacy your health insurance plan wants you to use. When we check your coverage, we also refer you to a specialty pharmacy that can ship your Genentech medicine to your home or doctor's office.

Your specialty pharmacy might call you to confirm insurance and shipping details. Be sure you return all calls from the specialty pharmacy. This helps them send your Genentech medicine on time.

The effectiveness of ENSPRYNG was compared with a placebo (an inactive dummy treatment) in two clinical trials.

Improvements in eye bulging (also known as proptosis), double vision (also known as diplopia), and signs and symptoms of inflammation were seen in patients treated with ENSPRYNG.

In both studies, the key goal was to measure how effective ENSPRYNG was in reducing eye bulging compared to placebo. One of the studies did not meet this goal, meaning ENSPRYNG did not show a significant benefit compared to a placebo.

Want to know more about the ENSPRYNG clinical trials? See the results here.

ENSPRYNG may cause serious side effects including: infections, increased liver enzymes, low neutrophil counts, and serious allergic reactions.

All required vaccinations should be completed before starting ENSPRYNG.

Do not take ENSPRYNG if you:

• Are allergic to satralizumab-mwge or any of the other ingredients in ENSPRYNG.
• Have an active hepatitis B infection.
• Have active or untreated inactive (latent) tuberculosis.

These are not all the possible serious side effects with ENSPRYNG. Talk to your healthcare provider if you experience side effects while taking ENSPRYNG.

The most common side effects of ENSPRYNG were:

• Upper respiratory tract infections.
• Increased liver enzymes.

Additionally, low white blood cell (neutrophil) counts happened in less than 5% of patients.

These are not all the possible side effects of ENSPRYNG. Talk to your healthcare provider if you experience side effects while taking ENSPRYNG.

ENSPRYNG is a prefilled syringe given by an injection under the skin (subcutaneously). Once you've received your starting doses in the first 4 weeks of treatment, and have been trained and approved by your healthcare provider to self-inject, you'll be able to take ENSPRYNG at home yourself or with the help of a trained caregiver.

ENSPRYNG is available as a 120 mg prefilled syringe, and will be available as 120 mg and 180 mg autoinjector from early 2027.

Your healthcare provider will train you or your caregiver on how to properly inject ENSPRYNG.

If you'd like to adjust your dosing schedule, please talk to your doctor before doing so. They can help you find a safe solution that better fits your needs.

If you miss a dose of ENSPRYNG, call your doctor right away to find out when to take your next dose. Do not take an extra dose or double up to make up for a missed dose.

Speak with your doctor if you have any questions about how to restart treatment or if it has been more than 8 weeks since your last dose of ENSPRYNG.

ENSPRYNG should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) in its original carton. You can store ENSPRYNG at room temperature for a total of 8 days, giving you control over where you take it.

If the seal is broken, your medication has expired, or there are any other issues with your medication, contact your doctor immediately. Do not use the medication.

If you have experienced this, we encourage everyone to report any side effects related to ENSPRYNG or other Genentech prescription drugs to Genentech, Inc. at 888-835-2555 and the FDA at 800-FDA-1088.

Yes, you can take ENSPRYNG with you wherever you'd like, as long as your healthcare provider has trained and approved you to self-inject. Just be sure to stick to your regular dosing schedule and keep ENSPRYNG in a travel cooler whenever possible. You can store ENSPRYNG at room temperature (no higher than 86°F/30°C) for a total of 8 days, giving you control over where you take it.

It's important to stay on track with your ENSPRYNG injections. Keep track of the date of each dose and where it was given (left abdomen, right abdomen, left thigh, or right thigh), as you'll need to rotate injection sites. Make note of any reactions and how you felt, so you can discuss with your doctor. It can help to add reminders of your upcoming injection days in your phone or calendar.

TED stands for thyroid eye disease. It’s a condition where the body’s immune system mistakenly attacks the tissues around the eye, causing inflammation and swelling.

Common TED symptoms include:

• Eye appearance: bulging eyes (proptosis), a fixed "staring" expression, and retracted eyelids.
• Discomfort: a gritty, sandy feeling, persistent dryness, or excessive watering.
• Swelling: puffiness, redness, or a feeling of fullness in the eyelids.
• Pain and movement: ache in or behind the eyes (especially when looking in different directions) and stiffness in eye movement.
• Vision changes: blurry or double vision, and sensitivity to bright lights (photophobia).

Your Case Manager from Genentech Access Solutions can help you understand your insurance coverage and assistance options. There may be options to help you afford your medication, no matter what type of health insurance you have.

For more information, visit the Financial Assistance Options page or call 844-NSPRYNG (844-677-7964).

Yes. you can find out more about treatment with ENSPRYNG on the Helpful resources page.