ENSPRYNG is a prescription medication approved for NMOSD in AQP4-IgG(+) adults that has been proven to reduce the risk of relapse. It is also the only self-administered subcutaneous injection given under the skin for NMOSD. If your healthcare provider determines it is appropriate and after proper training, you or your caregiver have the ability to give it in the comfort of your own home.

ENSPRYNG is for AQP4-IgG(+) adult patients with NMOSD. Your healthcare provider will determine the most appropriate way to use ENSPRYNG, as it has been evaluated alone or with certain immunosupressive therapies (azathioprine, mycophenolate mofetil, or oral corticosteroids).

Do not take ENSPRYNG if you:

• are allergic to ENSPRYNG or any of the ingredients in ENSPRYNG
• have an active hepatitis B infection
• have active or untreated inactive (latent) tuberculosis

The specific way ENSPRYNG works is not completely understood, but it is thought to affect the protein interleukin 6 (IL-6). ENSPRYNG is the first treatment for NMOSD designed to block IL-6, a protein made by immune cells in our bodies that may play a key role in the inflammation that occurs in people with NMOSD.

Every patient is unique. So your healthcare provider will determine the most appropriate way to use ENSPRYNG, as it has been evaluated alone or with immunosupressive therapy (IST), such as azathioprine, mycophenolate mofetil, or oral corticosteroids. Talk to your healthcare provider about all your medicines before starting treatment.

ENSPRYNG might be different from other medicines you’ve taken. First, talk to your healthcare provider to see if ENSPRYNG is right for you. If you’re prescribed ENSPRYNG, you won’t pick it up from your local drugstore; instead, a Specialty Pharmacy will deliver ENSPRYNG to your home.

In 2 clinical studies, ENSPRYNG was proven to reduce the risk for relapse when used by itself or with certain immunosuppressive therapy. In both studies, more patients were relapse-free with ENSPRYNG than with placebo.

Get more details about ENSPRYNG study results by visiting the About ENSPRYNG page.

ENSPRYNG may cause serious side effects including: infections, increased liver enzymes, and low neutrophil counts. All required vaccinations should be completed before starting ENSPRYNG. Do not take ENSPRYNG if you are allergic to satralizumab-mwge or any of the ingredients in ENSPRYNG, have an active hepatitis B infection, or have active or untreated inactive (latent) TB.

These are not all the possible serious side effects with ENSPRYNG. Talk to your healthcare provider if you experience side effects while taking ENSPRYNG.

The most common side effects of ENSPRYNG include:

• sore throat/runny nose (nasopharyngitis)
• rash
• fatigue
• extremity pain
• headache
• upper respiratory tract infection
• nausea
• inflammation of the stomach lining (gastritis)
• joint pain (arthralgia)

These are not all the possible side effects of ENSPRYNG. Talk to your healthcare provider if you experience side effects while taking ENSPRYNG.

ENSPRYNG is taken as a subcutaneous injection under the skin. During the first 4 weeks, you will have 3 starting doses (injections) of ENSPRYNG. You will receive 1 prefilled syringe (120 mg of ENSPRYNG) 2 weeks apart for each dose. After the starting doses, ongoing doses will be taken every 4 weeks.

Your healthcare provider should train you on the proper technique for subcutaneous injection, which is an injection into the tissue under the skin. You can also set up a free one-on-one supplemental injection training visit with an ENSPRYNG Clinical Education Manager. Once trained and if your healthcare provider determines it is appropriate, you or a caregiver can administer your injections.

Talk with your healthcare provider if you want to adjust your dosing schedule. They can help you find a solution that safely meets your needs.

If a starting dose is missed, you should take it immediately, then maintain the 2-week dosing interval from your new starting date until the first 3 doses are complete, and then continue with ongoing doses every 4 weeks.

If an ongoing dose is missed, you should take it immediately, wait the 4-week interval from your new starting date, and continue with ongoing doses every 4 weeks.

Speak with your healthcare provider if you have any questions about how to restart treatment or if it has been more than 8 weeks since your last dose of ENSPRYNG.

If the seal is broken, your medication has expired, or there are any other issues with your medication, contact your healthcare provider immediately. Do not use the medication.

If you have experienced this, we encourage everyone to report any side effects related to ENSPRYNG or other Genentech prescription drugs to Genentech, Inc. at 1-888-835-2555 and the FDA at 1-800-FDA-1088.

Yes. Because you may be able to administer ENSPRYNG yourself, you can take it with you when you travel. Be sure to stick to your regular schedule and keep ENSPRYNG in a travel cooler whenever possible. ENSPRYNG should not be unrefrigerated for more than 8 days.

It's important to stay on track with your ENSPRYNG injections. Keep track of the date of each dose and where it was given (left abdomen, right abdomen, left thigh, or right thigh), as you'll need to rotate injection sites. Make note of any reactions and how you felt, so you can discuss with your doctor. It can help to set reminders of your upcoming injection days in your phone or calendar.

NMOSD stands for neuromyelitis optica spectrum disorder and is sometimes called neuromyelitis optica or NMO for short. It is a rare, chronic autoimmune disease marked by inflammation of the optic nerves and spinal cord. NMOSD can cause relapses that result in new or worsening symptoms.

NMOSD symptoms can be different from person to person, so it's important to discuss any you experience with your healthcare provider. Common symptoms include:

• blurred vision
• inability to see colors
• complete vision loss
• pain
• weakness
• paralysis in the legs
• loss of sensation or numbness
• bladder and bowel control issues
• severe hiccups
• vomiting
• nausea

AQP4-IgG stands for aquaporin-4 immunoglobulin G. It's an antibody produced by the immune system that helps in diagnosing NMOSD. If you'd like to know your AQP4-IgG antibody status, talk to your healthcare provider.

Based on current understanding of NMOSD, damage caused by relapses is often irreversible and accumulates or adds up over time. This is what leads to NMOSD symptoms and to symptoms getting worse over time.

Anytime you experience a relapse, call your healthcare provider immediately.